Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMIWCE)

Drug Name

Sifuvirtide Drug Info

Synonyms

FS-0101; HIV fusion inhibitor (oral), FusoGen; HIV gp41 protein inhibitor (oral), FusoGen; Sifuvirtide (oral, HIV); Sifuvirtide (oral, HIV), FusoGen

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Glycoprotein 41 (HIV gp41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enfuvirtide	DM7YPM1	Human immunodeficiency virus infection	1C62	Approved	[3]
ITV-1	DMCJX79	Human immunodeficiency virus infection	1C62	Phase 2	[4]
T-1249	DMB2NP8	Human immunodeficiency virus infection	1C62	Phase 1/2	[5]
MaC46/M87o	DMIRG15	Human immunodeficiency virus-1 infection	1C62	Phase 1/2	[6]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[7]
Combinectin	DMTLP1N	Human immunodeficiency virus infection	1C62	Phase 1	[8]
Gp41 HIV-1 vaccine	DM9JV80	Human immunodeficiency virus infection	1C62	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Glycoprotein 41 (HIV gp41)	TTG90S6	ENV_HV1H2	Modulator	[2]

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References

1	The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance. J Antimicrob Chemother. 2014 Oct;69(10):2759-69.
2	Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.J Biol Chem.2012 Feb 24;287(9):6788-96.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of Immunotech Laboratories.
5	HIV entry inhibitors in clinical development. Curr Opin Pharmacol. 2002 Oct;2(5):523-8.
6	DOI: 10.1038/mt.sj.6300124
7	An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.
8	Clinical pipeline report, company report or official report of ViiV Healthcare.
9	Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617.