Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMJDYI)

Drug Name

BMY-30123 Drug Info

Synonyms

Retinoic acid 4-acetamidophenyl ester; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2(E),4(E),6(E),8(E)-nonatetraenoic acid 4-acetamidophenyl ester

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 6505275
CAS Number: CAS 1959588-74-9
TTD Drug ID: DMMJDYI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Retinoic acid receptor (RAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[3]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[5]
Adapalene	DMX2358	Acne vulgaris	ED80	Approved	[6]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[7]
Peretinoin	DMESAZK	Hepatocellular carcinoma	2C12.02	Phase 3	[8]
13-cis-retinoic acid	DMTZ1A5	Glioma	2A00.0	Phase 3	[9]
Velac Gel	DMXHI89	Acne vulgaris	ED80	Phase 3	[10]
Amsilarotene	DMOB01U	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
LAS-41001	DMXZ4BK	Rosacea	ED90.0	Discontinued in Preregistration	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor (RAR)	TTOD7B3	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003321)
2	The pharmacology of a novel topical retinoid, BMY 30123: comparison with tretinoin. J Pharm Pharmacol. 1992 May;44(5):379-86.
3	Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
4	Retinoids--which dermatological indications will benefit in the near future Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.
5	Retinoid agonist isotretinoin ameliorates obstructive renal injury. J Urol. 2003 Oct;170(4 Pt 1):1398-402.
6	A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4.
7	National Cancer Institute Drug Dictionary (drug id 39582).
8	Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191.
9	13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7.
10	Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
11	Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. J Clin Oncol. 2002 Aug 15;20(16):3522-32.
12	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027956)