Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMKN4Q)

• Drug Name: NOX-A12 Drug Info
• Synonyms: Ocular antineovascularisation agent/angiogenesis inhibitor (diabetic retinopathy/AMD), NOXXON; SDF-1 inhbitor (spiegelmer, stem cell transplantation), NOXXON; CXCL12 inhibitor (spiegelmer, diabetic retinopathy/AMD/stem cell transplantation), Noxxon

Indication

Disease Entry	ICD 11	Status	REF
Macular degeneration	9B78.3	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMMKN4Q

Molecule-Related Drug Atlas

Drug(s) Targeting Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dociparstat sodium	DMQLSMB	Acute myeloid leukaemia	2A60	Phase 3	[3]
MyoCell SDF-1	DMS9GE1	Heart failure	BD10-BD13	Phase 3	[4]
SDF-1	DM80HOV	Heart failure	BD10-BD13	Phase 2	[5]
REC-02	DMHT5XV	Congestive heart failure	BD10	Phase 1	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Stromal cell-derived factor 1 (CXCL12)	TT4UGTF	SDF1_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT01194934) NOX-A12 Multiple Ascending Dose Study in Healthy Volunteers. U.S. National Institutes of Health.
• [2] SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015 Dec;28(12):1426-35.
• [3] Clinical pipeline report, company report or official report of Chimerix.
• [4] Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011 Feb;11(2):189-97.
• [5] SDF-1 in myocardial repair. Gene Ther. 2012 Jun;19(6):583-7.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)