Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMQ7BY)

Drug Name

Fitusiran Drug Info

Synonyms

ALN-AT3SC

Indication

Disease Entry	ICD 11	Status	REF
Hemophilia	3B10.0	Phase 3	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SERPINC1 messenger RNA (SERPINC1 mRNA)	TTZ4MD5	ANT3_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT03549871) A Study of Fitusiran in Severe Hemophilia A and B Patients Previously Receiving Factor or Bypassing Agent Prophylaxis (ATLAS-PPX). U.S. National Institutes of Health.
2	Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy. N Engl J Med. 2017 Aug 31;377(9):819-828.