Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN6HE3)

Drug Name
S136492 Drug Info
Synonyms
(E)-2-(2-(quinolin-2-yl)vinyl)phenol; CHEMBL127545; 2-[(E)-2-(quinolin-2-yl)ethenyl]phenol; 143816-42-6; Quininib; 2-(2-(quinolin-2-yl)vinyl)phenol; (6E)-6-[(2E)-2-(1H-quinolin-2-ylidene)ethylidene]cyclohexa-2,4-dien-1-one; AC1OATYA; AC1NW9KR; Cambridge id 5719593; AC1NZV89; AC1Q791J; Quininib, > SCHEMBL10325190; CHEBI:133170; MolPort-001-824-964; MolPort-000-712-889; ZINC3882963; STL044348; BDBM50001270; 2-(2-Quinolin-2-yl-vinyl)-phenol; AKOS015955311; AKOS005697868; 2-[(E)-2-(quinolin-2-yl)vinyl]phenol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135411330
ChEBI ID
CHEBI:133170
TTD Drug ID
DMN6HE3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Endothelin-converting enzyme 2 (ECE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CGS 35066 DMCHT27 Discovery agent N.A. Investigative [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelin-converting enzyme 2 (ECE2) TT5U914 ECE2_HUMAN Inhibitor [2]

References

1 Endothelin-converting enzyme 2 differentially regulates opioid receptor activity. Br J Pharmacol. 2015 Jan;172(2):704-19.
2 Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem. 2008 Jun 26;51(12):3378-87.
3 The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system. Expert Opin Investig Drugs. 2002 Nov;11(11):1537-52.