Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN7QBE)

Drug Name

GANTACURIUM CHLORIDE Drug Info

Synonyms

AV-430A; GW-0430; GW-280430A; Gantacurium chloride; (Z)-2-Chlorofumaric acid 1-[3-[6,7-dimethoxy-2(S)-methyl-1(R)-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium-2-yl]propyl] 4-[3-[6,7-dimethoxy-2(R)-methyl-1(S)-(3,4,5-trimethoxyphenyl)-1,2,3

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 10772467
CAS Number: CAS 213998-46-0
TTD Drug ID: DMN7QBE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Nicotinic acetylcholine receptor (nAChR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[3]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[4]
Pancuronium	DMB0VY8	Anaesthesia	9A78.6	Approved	[5]
Atracurium	DM42HXN	Anaesthesia	9A78.6	Approved	[5]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[6]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[7]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[8]
BMS-954561	DM7XV4R	Diabetic neuropathy	8C0Z	Phase 2	[9]
ASM-024	DM35S2I	Asthma	CA23	Phase 2	[10]
NIC-002	DMKLJMI	Nicotine dependence	6C4A.2	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00235976) The Efficacy and Safety of Gantacurium Chloride for Injection in Tracheal Intubation in Healthy Adult Patients Undergoing Surgery Under General Anesthesia. U.S. National Institutes of Health.
2	Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology. 2010 April; 112(4): 892-899.
3	Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 2009 Aug;57(2):183-91.
4	Functional versus chemical diversity: is biodiversity important for drug discovery. Trends Pharmacol Sci. 2002 May;23(5):225-31.
5	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
6	Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
9	EP patent application no. 2774991, Drug delivery system for use in the treatment or diagnosis of neurological disorders.
10	Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma. Can Respir J. 2015 Jul-Aug;22(4):230-4.
11	Therapeutic advances in the treatment of nicotine addiction: present and future. Ther Adv Chronic Dis. 2010 May; 1(3): 95-106.