Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNAT5V)

Drug Name

GW-2592X Drug Info

Synonyms

Azepanone inhibitors, GlaxoSmithKline; Cathepsin K inhibitors (bone disorder); Cathepsin K inhibitors, SmithKline Beecham; GW-2637X; GW-2934X; GW-9696X; SB-237632; SB-244875; SB-267320; SB-271194; SB-327537; SB-331750; SB-357114; SB-432238; SB-553484; Cathepsin K inhibitors (bone disorder), GlaxoSmithKline

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Preclinical	[1]
Bone disease	FC0Z	Investigative	[2]

Cross-matching ID

TTD Drug ID: DMNAT5V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cathepsin K (CTSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Odanacatib	DM1EO3G	Osteoporosis	FB83.0	Phase 3	[3]
SAR-114137	DMZ1XR5	Pain	MG30-MG3Z	Phase 1	[4]
VEL-0230	DMDSC63	Rheumatoid arthritis	FA20	Phase 1	[5]
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[6]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[6]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[6]
PMID25399719-Compound-17	DMRXKJZ	N. A.	N. A.	Patented	[7]
PMID27998201-Compound-15	DMOB8LU	Pain	MG30-MG3Z	Patented	[6]
Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1	DM1SH5R	Pain	MG30-MG3Z	Patented	[6]
PMID27998201-Compound-8	DMZK0SY	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin K (CTSK)	TTDZN01	CATK_HUMAN	Inhibitor	[2]

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References

1	Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350).
3	A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
4	From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
5	Discovery and parallel synthesis of a new class of cathepsin K inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.
6	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
7	An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.