Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNI0KO)

Drug Name
Denosumab Drug Info
Synonyms Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Drug-induced osteoporosis Approved [1]
Osteoporosis FB83.0 Approved [2]
Postmenopausal osteoporosis FB83.11 Approved [3]
Prostate cancer 2C82.0 Phase 3 [3]
Rheumatoid arthritis FA20 Phase 2 [3]
Cross-matching ID
TTD Drug ID
DMNI0KO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Osteoclast differentiation factor (ODF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CEP-37251 DMYXQBF Bone metastases 2D50 Phase 1 [5]
ALX-0141 DMBGI74 Osteoporosis FB83.0 Phase 1 [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Osteoclast differentiation factor (ODF) TT9E8HR TNF11_HUMAN Not Available [4]

References

1 Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview. Int J Mol Sci. 2023 Mar 18;24(6):5814.
2 Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study. BMJ. 2023 Apr 18;381:e073435.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886).
4 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5 This week in therapeutics Cancer. SciBX 3(40); doi:10.1038/scibx.2010.1202. Oct. 14, 2010
6 Clinical pipeline report, company report or official report of Ablynx.