Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNLD6W)

Drug Name

SCH 44643 Drug Info

Synonyms

SCH 44643; 133330-43-5; AC1L466E

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Platelet activating factor (PAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indol-3-carbinol	DMXJO20	Fungal infection	1F29-1F2F	Preclinical	[2]
F-0401	DMR1X2U	N. A.	N. A.	Terminated	[3]
UR-12670	DM7F94W	N. A.	N. A.	Terminated	[4]
SRI 63-441	DMMPSY2	N. A.	N. A.	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet activating factor (PAF)	TT27K59	NOUNIPROTAC	Inhibitor	[1]

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References

1	Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. J Pharm Biomed Anal. 1996 Dec;15(3):343-7.
2	Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta Med. 1999 Feb;65(1):39-42.
3	Protective effects of a novel calcium antagonist with platelet-activating factor-antagonistic action, F-0401, against ischemic brain damage. Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):266-78.
4	Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. Kidney Int. 1999 Nov;56(5):1798-808.
5	Pharmacologic modulation of experimental postischemic hepatic function. Ann Surg. 1989 Feb;209(2):200-10.