Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNU1YR)

Drug Name

2S,4R-4-METHYLGLUTAMATE Drug Info

Synonyms

(2S,4R)-4-Methylglutamic acid; 31137-74-3; (2S,4R)-2-amino-4-methylpentanedioic acid; 2S,4R-4-Methylglutamate; CHEMBL288166; 4-Methylglutamic acid; 4-Methylglutamate; (4r)-4-methyl-l-glutamic acid; threo-gamma-Methylglutamate; 2-Amino-4-methyl-pentanedioic acid; 14561-55-8; 59685-03-9; NSC 41355; Tocris-0903; AC1L3VAT; SYM; Biomol-NT_000218; AC1Q5QI2; SCHEMBL594187; BPBio1_001308; CTK5B0310; KRKRAOXTGDJWNI-DMTCNVIQSA-N; MolPort-003-848-893; ZINC896091; Glutamic acid, 4-methyl- (VAN); (2S,4R)-4-methyl gluta

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 95883
CAS Number: CAS 77842-39-8
TTD Drug ID: DMNU1YR
VARIDT Drug ID: DR00937

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutamate receptor ionotropic kainate 1 (GRIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[2]
LY293558	DM4N6EK	Pain	MG30-MG3Z	Phase 2	[3]
NS 1209	DM9EFH0	Epilepsy	8A60-8A68	Phase 2	[4]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[5]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[6]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[1]
SYM2081	DM30WDL	Discovery agent	N.A.	Investigative	[6]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[7]
dysiherbaine	DM0EBAF	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic kainate 1 (GRIK1)	TT0MYE2	GRIK1_HUMAN	Inhibitor	[1]

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References

1	Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103.
2	Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005 May;10(2):323-43.
3	Pharmacogenetics of new analgesics. Br J Pharmacol. 2011 Jun;163(3):447-60.
4	The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.
5	4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450).
7	Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.