Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNZBRY)

Drug Name

Capreomycin Drug Info

Synonyms

Capreomycin Sulfate Standard; Capreomycin sulphate; Caprocin (Disulfate); Ogostal (Disulfate); (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(6R)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(6R)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Pulmonary tuberculosis	1B10.Z	Approved	[2]
Mycobacterium infection	1B10-1B21	Phase 2	[3]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 3000502
CAS Number: CAS 11003-38-6
TTD Drug ID: DMNZBRY

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial 70S ribosomal RNA (Bact 70S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capreomycin Sulfate	DM346QI	Tuberculosis	1B10-1B1Z	Approved	[5]
Viomycin sulfate	DMZYLFC	Bacterial infection	1A00-1C4Z	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 70S ribosomal RNA (Bact 70S rRNA)	TTIA0J5	NOUNIPROTAC	Binder	[4]

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References

1	Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
2	Capreomycin FDA Label
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics. 2007 Sep;278(3):307-15.
5	The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.Nat Struct Mol Biol.2010 Mar;17(3):289-93.
6	The antibiotic viomycin traps the ribosome in an intermediate state of translocation.Nat Struct Mol Biol.2007 Jun;14(6):493-7.