Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO8LPZ)

Drug Name

Beta-Hydroxy Aspartic Acid Drug Info

Synonyms

71653-06-0; 2-Amino-3-hydroxysuccinic Acid; Malic acid, 3-amino-; 2-amino-3-hydroxybutanedioic acid; d,l-threo-3-HYDROXYASPARTIC ACID; NSC618260; 1860-87-3; CHEBI:83981; 2-amino-3-hydroxy-butanedioic acid; 3-Hydroxy-DL-aspartic acid; Aspartic acid, 3-hydroxy-; D,L-Threo-b-hydroxyaspartic acid; DL-threo-3-Hydroxyaspartic acid; 3-aminomalic acid; EINECS 275-771-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5425
ChEBI ID: CHEBI:83981
CAS Number: CAS 71653-06-0
TTD Drug ID: DMO8LPZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Coagulation factor Xa (F10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apixaban	DM89JLN	Thrombosis	DB61-GB90	Approved	[2]
Rivaroxaban	DMQMBZ1	Deep vein thrombosis	BD71	Approved	[3]
DU-176b	DMCIJBH	Atrial fibrillation	BC81.3	Approved	[4]
Emicizumab	DM0AQ83	Factor VIII deficiency	3B10	Approved	[5]
BETRIXABAN	DM2C4RF	Venous thromboembolism	BD72	Approved	[6]
Lmw heparin	DMJPD06	Coagulation defect	3B10.0	Approved	[7]
Nadroparin calcium	DMBNKST	Coagulation defect	3B10.0	Approved	[8]
Fondaparinux sodium	DMWS3FH	Deep vein thrombosis	BD71	Approved	[9]
Danaparoid	DM6CLBN	Deep venous clot	BD71	Approved	[10]
Coagulation Factor IX	DM8HBJI	Haemophilia B	3B11.0	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor Xa (F10)	TTCIHJA	FA10_HUMAN	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	Pfizer. Product Development Pipeline. March 31 2009.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2359).
5	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
6	Company report (Portola)
7	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
8	Serum zinc concentrations: contamination from laboratory equipment. JPEN J Parenter Enteral Nutr. 1979 May-Jun;3(3):179-81.
9	Biochemistry and clinical pharmacology of new anticoagulant agents. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):218-24.
10	Effect of factor X inhibition on coagulation activation and cytokine induction in human systemic inflammation. J Infect Dis. 2002 Nov 1;186(9):1270-6.
11	Haemophilia B: Christmas disease. Expert Opin Pharmacother. 2005 Aug;6(9):1517-24.