Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOPRQ7)

• Drug Name: 4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide Drug Info
• Synonyms: CHEMBL201718; 4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide; BDBM50181477; 4-[(3-benzyloxy-2-pyridyl)carbamoylamino]benzamide; Benzamide, 4-[[[[3-(phenylmethoxy)-2-pyridinyl]amino]carbonyl]amino]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11574097
  TTD Drug ID: DMOPRQ7

Molecule-Related Drug Atlas

Drug(s) Targeting Rotamase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[2]
3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide	DM60YGF	Discovery agent	N.A.	Investigative	[1]
(3r)-1-Acetyl-3-Methylpiperidine	DM49YTN	Discovery agent	N.A.	Investigative	[3]
7-AMINO-4-METHYL-CHROMEN-2-ONE	DMC8O3Z	Discovery agent	N.A.	Investigative	[4]
1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea	DMDZAVU	Discovery agent	N.A.	Investigative	[1]
Ethyl Oxo(Piperidin-1-Yl)Acetate	DM9KF0H	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rotamase A (PPIA)	TTL2ADK	PPIA_HUMAN	Inhibitor	[1]

References

• [1] Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem. 2006 Feb 9;49(3):900-10.
• [2] Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc. 2009 Jan 14;131(1):147-52.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.