Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOSCBF)

Drug Name
SAR-3419 Drug Info
Synonyms HuB4-DM4; DM4-conjugated anti-CD19 monoclonal (cancer), sanofi-aventis/ImmunoGen
Indication
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMOSCBF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting B-lymphocyte surface antigen B4 (CD19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tisagenlecleucel DMM9BJD Acute lymphoblastic leukaemia 2A85 Approved [2]
Blinatumomab DMGECIJ Acute lymphoblastic leukaemia 2A85 Approved [3]
Axicabtagene ciloleucel DMYHN59 Diffuse large B-cell lymphoma 2A81 Approved [4]
Lisocabtagene maraleucel DMP45ME Large B-cell lymphoma 2A81 Approved [5]
Inebilizumab DMI0RHA Neuromyelitis optica spectrum disorder 8E4A.0 Approved [6]
Tecartus DMYQCWT Mantle cell lymphoma 2A85.5 Approved [7]
Loncastuximab tesirine DMXSVGI Diffuse large B-cell lymphoma 2A81 Approved [8]
Obexelimab DMVIC4J IgG4 related disease 4A43.0 Phase 3 [9]
MOR-208 DMDQOWT Diffuse large B-cell lymphoma 2A81 Phase 2/3 [10]
CART-19 DMST3FM Acute lymphoblastic leukaemia 2A85 Phase 2/3 [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B-lymphocyte surface antigen B4 (CD19) TTW640A CD19_HUMAN Not Available [1]

References

1 A dose-escalation study of SAR3419, an anti-CD19 antibody maytansinoid conjugate, administered by intravenous infusion once weekly in patients with relapsed/refractory B-cell non-Hodgkin lymphoma. Clin Cancer Res. 2014 Jan 1;20(1):213-20.
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
8 Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma. Blood. 2021 May 13;137(19):2634-2645.
9 Emerging B-Cell Therapies in Systemic Lupus Erythematosus. Ther Clin Risk Manag. 2021 Jan 14;17:39-54.
10 A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL. Blood. 2014 Dec 4;124(24):3553-60.
11 ClinicalTrials.gov (NCT03027739) CART-19 Cells For MRD Positive CD19+ ALL