Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOVBSF)

Drug Name

Tresperimus Drug Info

Synonyms

LF-08-0299

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Discontinued in Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Metabolized By Copper amine oxidase (AOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
tyramine	DM4UXT1	Discovery agent	N.A.	Investigative	[3]
PHENETHYLAMINE	DMX0G4F	Discovery agent	N.A.	Investigative	[3]
Benzylamine	DMRM6ES	N. A.	N. A.	Investigative	[3]
Methylamine	DMTPL4W	N. A.	N. A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Copper amine oxidase (AOC3)^{Main DME}	DE6SOC5	AOC3_HUMAN	Substrate	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004804)
2	Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO). Fundam Clin Pharmacol. 2002 Dec;16(6):461-70.
3	The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57.