Details of the Drug-Related molecule(s) Interaction Atlas

GR-175737 Drug Info

GR-175737; CHEMBL276798; GR 175737; SCHEMBL195040; GTPL1243; BDBM50070213; 3-[(4-chlorophenyl)methyl]-5-[2-(3H-imidazol-4-yl)ethyl]-1,2,4-oxadiazole; GR175737; L015003; 3-(4-Chloro-benzyl)-5-[2-(1H-imidazol-4-yl)-ethyl]-[1,2,4]oxadiazole; 1,2,4-Oxadiazole, 3-((4-chlorophenyl)methyl)-5-(2-(1H-imidazol-4-yl)ethyl)-; 203874-78-6

Cross-matching ID

PubChem CID

9838905

CAS Number

CAS 176860-26-7

TTD Drug ID

DMOY8UA

General Information of Drug (ID: DMOY8UA)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[2]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[3]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[4]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[5]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[6]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[7]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[8]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[9]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[7]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[10]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
7	SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
8	Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
9	A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)