Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOZAMN)

Drug Name

TAK-935 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Dravet syndrome	8A61.11	Phase 2	[1]
LennoxGastaut syndrome	8A62.1	Phase 2	[1]
Tuberous sclerosis	LD2D.2	Phase 2	[1]
Glutamate excitotoxity	5C73	Phase 1	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

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Drug(s) Targeting Cholesterol 24-hydroxylase (CYP46A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25514969-Compound-Figure3	DM7D12Y	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-8	DM2NVLZ	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-10	DME0XS4	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-9	DMAEZB1	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-Figure2-3	DMUYVOP	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-11	DMUPL0W	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-Figure2-4	DMXSAN7	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-13	DMQB03U	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-12	DMOE5N0	N. A.	N. A.	Patented	[4]
PMID25514969-Compound-Figure2-2	DMC6S0W	N. A.	N. A.	Patented	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesterol 24-hydroxylase (CYP46A1)	TT4EB85	CP46A_HUMAN	Inhibitor	[3]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT02201056) Safety, Tolerability, and Pharmacokinetics of Escalating Single Doses of TAK-935. U.S. National Institutes of Health.
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040983)
4	Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7.