General Information of Drug (ID: DMPHUBO)

Drug Name
PLD-177 Drug Info
Synonyms PLR-13; PLR-2146; Inhaled steroids (asthma), PLIVA; PLD-177 (inhaled, Clickhaler), PLIVA/Innovata Biomed
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Terminated [1]
Cross-matching ID
TTD Drug ID
DMPHUBO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimexolone DMTAREC Arthritis FA20 Approved [2]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [3]
D-5519 DM9FAJM Asthma CA23 Phase 3 [4]
Dexamethasone palmitate DMCMT4V Choroidal neovascularization 9B76 Phase 1/2 [5]
RPR-106541 DMRGC5B Asthma CA23 Discontinued in Phase 2 [6]
Rofleponide DM6OSPQ Allergic rhinitis CA08.0 Discontinued in Phase 2 [7]
AD-121 DMB8XJM Rheumatoid arthritis FA20 Discontinued in Phase 1/2 [2]
GW-250495 DMWJZAP Asthma CA23 Discontinued in Phase 1 [2]
Steroid hormone conjugates DMOJM08 Cachexia MG20 Terminated [8]
daidzein DMRFTJX Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020887)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622).
3 Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6.
4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007199)
5 Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet. 2002 Jul 20;360(9328):211-8.
6 Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602.
7 Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.
8 The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf). 1998 Oct;49(4):421-32.
9 Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91.