General Information of Drug (ID: DMPOX4Q)

Drug Name
ML290 Drug Info
Synonyms ML 290; compound 8 [PMID: 23764525]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
56593349
TTD Drug ID
DMPOX4Q

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug(s) Targeting Relaxin receptor 1 (RXFP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RLX030 DMXIRA0 Acute heart failure BD10-BD13 Approval submitted [3]
AZD5462 DM2QQZO Cardiovascular disease BA00-BE2Z Phase 1 [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Relaxin receptor 1 (RXFP1) TTMAHD1 RXFP1_HUMAN Modulator (allosteric modulator) [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8322).
2 Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1). Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010.
3 Design of the RELAXin in acute heart failure study. Am Heart J. 2012 Feb;163(2):149-55.e1.
4 Clinical pipeline report, company report or official report of AstraZeneca