Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPR8E9)

Drug Name
Lonapegsomatropin Drug Info
Synonyms ACP-001; TransCon-PEG Growth Hormone; TransCon-PEG-hGH; Growth hormone (TransCon, subcutaneous sustained-release), Ascendis Pharma
Indication
Disease Entry ICD 11 Status REF
Growth failure LD2F.1Y Approved [1]
Growth hormone deficiency 5A61.3 Phase 2 [2]
Cross-matching ID
TTD Drug ID
DMPR8E9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HGH-CTP DMXAZ47 Growth hormone deficiency 5A61.3 Phase 3 [3]
Albutropin DMWAL73 Growth failure LD2F.1Y Phase 3 [4]
VRS-317 DMWMT5N Growth hormone deficiency 5A61.3 Phase 3 [5]
Somatropin intranasal rhGH DMK3RL8 Growth hormone deficiency 5A61.3 Phase 2 [6]
YPEG-Somatropin DMCM0K6 Growth hormone deficiency 5A61.3 Phase 1 [7]
ARX-201 DMS0LCZ Growth failure LD2F.1Y Discontinued in Phase 2 [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatotropin (GH1) TTT3YKH SOMA_HUMAN Modulator [2]

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761177.
2 ClinicalTrials.gov (NCT01947907) Safety, PK/PD and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD). U.S. National Institutes of Health.
3 Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int J Nanomedicine. 2014; 9: 3527-3538.
4 Albutropin: a growth hormone-albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys. Eur J Pharmacol. 2002 Dec 5;456(1-3):149-58.
5 Company report (Versartis)
6 Long-term efficacy and safety of somatropin for adult growth hormone deficiency.Treat Endocrinol.2003;2(2):109-20.
7 Somatropin therapy in adults with Prader-Willi syndrome. Treat Endocrinol. 2004;3(3):153-60.
8 Company report (Avarx)