Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPVNDK)

Drug Name

Distamycin A Drug Info

Synonyms

distamycin a; Stallimycin; Distamycin; Herperetin; 636-47-5; DST-A; UNII-80O63P88IS; NSC82150; FI 6426; CHEMBL11252; 80O63P88IS; NCGC00018292-04; NSC 150528; Stallimycinum; Stallimycine; Estalimicina; Stallimicina; Distamicina A; DISTAMYCIN HYDROCHLORIDE; NSC150528; Dst-3; AC1Q5M1Q; AC1L1F7B; DSSTox_RID_81018; DSSTox_CID_25637; DSSTox_GSID_45637; DISTAMYCIN; STALLIMYCIN; SCHEMBL108585; DTXSID9045637; cid_6602691; UPBAOYRENQEPJO-UHFFFAOYSA-N; ZINC3872327; Tox21_110857; 6576-51-8 (mono-hydrochloride); NSC-82150; CCG-36393; BDBM50055659

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3115
ChEBI ID: CHEMBL11252
CAS Number: CAS 636-47-5
TTD Drug ID: DMPVNDK

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Human Deoxyribonucleic acid minor groove (hDNA min)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lurbinectedin	DMEFRTZ	Small-cell lung cancer	2C25.Y	Approved	[3]
Brostallicin	DMUI5PA	Breast cancer	2C60-2C65	Phase 2	[4]
Di-imidazole lexitropsin	DME4NH1	Discovery agent	N.A.	Investigative	[5]
Duocarmycin	DM0CQIP	Discovery agent	N.A.	Investigative	[6]
Netropsin	DMOW2QS	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
Selenium	DM25CGV	N. A.	N. A.	Approved	[9]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[10]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[15]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid minor groove (hDNA min)	TTOVXHF	NOUNIPROTAC	Binder (minor groove binder)	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Gene/Protein Processing	[2]
Thymidylate synthase	OTXTG0C7	TYSY_HUMAN	Gene/Protein Processing	[2]

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References

1	Development of distamycin-related DNA binding anticancer drugs. Expert Opin Investig Drugs. 2001 Sep;10(9):1703-14.
2	Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. Amino Acids. 2012 Feb;42(2-3):641-53.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
4	Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity. Expert Opin Investig Drugs. 2009 Dec;18(12):1939-46.
5	Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Structure. 1997 Aug 15;5(8):1033-46.
6	Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215.
7	Drug-DNA binding specificity: binding of netropsin and distamycin to poly(d2NH2A-dT). Biopolymers. 1990;30(1-2):223-7.
8	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
9	Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
10	Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003 Nov 28;278(48):47762-75.
11	Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
12	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
13	Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
14	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
15	Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
16	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.