Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ5GA9)

Drug Name

IS20 Drug Info

Synonyms

N-{2-(4-Methoxy-phenyl)-1-[(pyridin-3-ylmethyl)-carbamoyl]-vinyl}-benzamide; N-[(Z)-1-(4-methoxyphenyl)-3-oxo-3-(pyridin-3-ylmethylamino)prop-1-en-2-yl]benzamide; IS20; AC1NU0FP; MLS001215457; GTPL8518; CHEMBL1387323; SCHEMBL10192303; MolPort-019-741-307; HMS2912O06; ZINC13370608; AKOS000531635; SMR000608280; BAS 01151555; ST50247237; SR-01000425577; SR-01000425577-1; (2Z)-3-(4-methoxyphenyl)-2-(phenylcarbonylamino)-N-(3-pyridylmethyl)prop-2-ena mide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5442665
TTD Drug ID: DMQ5GA9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Prokineticin receptor-1 (PROKR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9475795, 80	DM0ZDL3	N. A.	N. A.	Patented	[3]
ZINC19658740	DMLZDAK	N. A.	N. A.	Patented	[4]
US9475795, 89	DMR6ODL	N. A.	N. A.	Patented	[3]
US9475795, 19	DMGPDEF	N. A.	N. A.	Patented	[3]
triazine compound PC10	DMCLA2D	Discovery agent	N.A.	Investigative	[5]
IS1	DMNF70P	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prokineticin receptor-1 (PROKR1)	TTB9CIL	PKR1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8518).
2	Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027.
3	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795.
4	Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273.
5	Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7.