Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQALR5)

Drug Name

Almorexant Drug Info

Synonyms

Almorexant [INN]; ACT-078573; (2R)-2-((1S)-6,7-dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

Indication

Disease Entry	ICD 11	Status	REF
Insomnia	7A00-7A0Z	Terminated	[1]
Sleep-wake disorder	7A00-7B2Z	Terminated	[1]

Cross-matching ID

PubChem CID: 23727689
CAS Number: CAS 871224-64-5
TTD Drug ID: DMQALR5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Orexin receptor type 1 (HCRTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB-649868	DMYLBOU	Insomnia	7A00-7A0Z	Phase 2	[3]
JNJ-61393215	DME2S4D	Major depressive disorder	6A70.3	Phase 2	[4]
AZD4041	DMEPQI4	Opioid use disorder	6C43.2Z	Phase 1	[5]
1,2-diamino cyclopentane-based derivative 25	DMEW0AT	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 5	DMCP15K	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 20	DM9PHIK	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 15	DMBY65W	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 13	DM10UX4	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 9	DM7I8ZV	N. A.	N. A.	Patented	[6]
1,2-diamino cyclopentane-based derivative 8	DM7JX8U	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Orexin receptor type 1 (HCRTR1)	TT60Q8D	OX1R_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2886).
2	Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
4	Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. Transl Psychiatry. 2020 Sep 7;10(1):308.
5	Clinical pipeline report, company report or official report of AstraZeneca
6	Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15.