Details of the Drug-Related molecule(s) Interaction Atlas

Homogentisic acid Drug Info

Homogenestic acid lactone; Homogentisic acid lactone; Homogentisic Acid gamma-Lactone; Homogentisic Acid?-Lactone; Homogentisic lactone; 2(3H)-Benzofuranone, 5-hydroxy-; 2,3-Dihydro-5-hydroxybenzofuran-2-one; 2688-48-4; 5-Hydroxy-2(3H)-benzofuranone; 5-Hydroxy-2-coumaranone; 5-Hydroxybenzofuran-2(3H)-one; 5-Hydroxybenzofuran-2-one; 5-hydroxy-1-benzofuran-2(3H)-one; 5-hydroxy-3-hydrobenzo[b]furan-2-one; 5-hydroxy-3H-1-benzofuran-2-one; A-Lactone; AC1L2PRA; AC1Q6ML0; EINECS 220-252-7; MLS002693363; NSC61996

Cross-matching ID

PubChem CID

75898

ChEBI ID

CHEBI:141343

CAS Number

CAS 2688-48-4

TTD Drug ID

DMQD0YW

INTEDE Drug ID

DR2015

General Information of Drug (ID: DMQD0YW)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loteprednol Etabonate	DM8QTJI	Eye inflammation	9A02	Approved	[2]
Prulifloxacin	DMOK965	Urinary tract infection	GC08	Approved	[3]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[1]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[1]
gamma-butyrolactone	DMDCZWY	Discovery agent	N.A.	Investigative	[1]
Coumaranone	DM7TCPG	N. A.	N. A.	Investigative	[1]
Dihydrocoumarin	DMGLX1R	N. A.	N. A.	Investigative	[1]
Gamma-thiobutyrolactone	DM83HUI	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Serum paraoxonase/arylesterase 1 (PON1)^{Main DME}	DESDN74	PON1_HUMAN	Substrate	[1]

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References

1	Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
2	Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
3	Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.