Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQD753)

Drug Name
SUVN-502 Drug Info
Synonyms SVN-502; 5-HT 6 receptor antagonist (Alzheimer's disease), Suven; 5-HT 6 receptor antagonist (cognitive/memory disorder), Suven
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Neurological disorder 6B60 Phase 2 [2]
Cross-matching ID
PubChem CID
10073773
CAS Number
CAS 701205-60-9
TTD Drug ID
DMQD753

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 6 receptor (HTR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LU AE58054 DMWGRQD Schizophrenia 6A20 Phase 3 [4]
SB-742457 DM6L4ZT Alzheimer disease 8A20 Phase 3 [5]
AVN 211 DMVB4OS Schizophrenia 6A20 Phase 2/3 [6]
SYN120 DMDF7XB Parkinson disease 8A00.0 Phase 2 [7]
AVN 101 DMJFLBC Alzheimer disease 8A20 Phase 2 [6]
SYN-120 DMPW0UL Alzheimer disease 8A20 Phase 2 [8]
PF-05212377 DMPVQYR Alzheimer disease 8A20 Phase 2 [9]
AVN 322 DMK2LGM Cognitive impairment 6D71 Phase 2 [5]
SAM-531 DMHVJZ6 Alzheimer disease 8A20 Phase 2 [10]
BVT-74316 DMEP321 Obesity 5B81 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 6 receptor (HTR6) TTJS8PY 5HT6R_HUMAN Antagonist [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of Suven Life Sciences.
3 Novel and Potent 5-Piperazinyl Methyl-N1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands. ACS Med Chem Lett. 2010 October 14; 1(7): 340-344.
4 Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33.
5 5-HT6 receptors and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2): 15.
6 Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Curr Opin Investig Drugs. 2010 January; 11(1): 80-91.
7 Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs. Nat Rev Drug Discov. 2018 Nov;17(11):804-822.
8 The Serotonin-6 Receptor as a Novel Therapeutic Target. Exp Neurobiol. 2011 December; 20(4): 159-168.
9 PF-05212377 Alzheimer's Disease (Phase 2). Pfizer.
10 Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation. ACS Chem Neurosci. 2013 Jan 16;4(1):191-9.
11 Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60.