Details of the Drug-Related molecule(s) Interaction Atlas

US9266828, C Drug Info

CHEMBL3951979; SCHEMBL15289221; BDBM207840; US9266828, C

Cross-matching ID

PubChem CID

71735826

TTD Drug ID

DMQEL1W

General Information of Drug (ID: DMQEL1W)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Dibasic-processing enzyme (Furin)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9266828, E	DMYUL2X	N. A.	N. A.	Patented	[1]
US9266828, B	DMYUDCE	N. A.	N. A.	Patented	[1]
DecRVKRCMK	DMAUILH	Coronavirus infection	1D92	Preclinical	[2]
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[3]
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[4]
MI-1148	DMCN91V	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dibasic-processing enzyme (Furin)	TTH9WF6	FURIN_HUMAN	Inhibitor	[1]

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References

1	Inhibitors of Furin and other pro-protein convertases. US9266828.
2	Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
3	Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
4	Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.
5	Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.