Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQLB3T)

Drug Name

KNI-10265 Drug Info

Synonyms

KNI-10265; CHEMBL509191; (4r)-3-[(2s,3s)-3-{[(2,6-Difluorophenoxy)acetyl]amino}-2-Hydroxy-4-Phenylbutanoyl]-N-[(1s,2r)-2-Hydroxy-2,3-Dihydro-1h-Inden-1-Yl]-5,5-Dimethyl-1,3-Thiazolidine-4-Carboxamide; 3kdd; BDBM50273737; JZQ

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44588309
TTD Drug ID: DMQLB3T

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Plasmepsin 2 (Malaria PLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9353089, 135	DMWG98Z	N. A.	N. A.	Patented	[2]
US9353089, 330	DMK02LS	N. A.	N. A.	Patented	[2]
US9353089, 327	DMB4MJ0	N. A.	N. A.	Patented	[2]
Pepstatin	DM9S1EA	Malaria	1F40-1F45	Terminated	[3]
Leupeptin	DMU075F	Malaria	1F40-1F45	Investigative	[3]
E-64	DMMOPAK	Discovery agent	N.A.	Investigative	[4]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[5]
PS-777621	DM3F7SD	Discovery agent	N.A.	Investigative	[6]
PS-662477	DMT4YFR	Discovery agent	N.A.	Investigative	[7]
KNI-10740	DMPWY6H	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Plasmepsin 2 (Malaria PLA2)	TTXMNHO	PLM2_PLAFA	Inhibitor	[1]

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References

1	Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60.
2	Compositions and methods for the treatment of malaria. US9353089.
3	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
4	Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
5	Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9.
6	High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
7	Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20.