Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQRL2Y)

• Drug Name: AC0010 Drug Info
• Synonyms: Avitinib; 1557267-42-1; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Avitinib free base; SCHEMBL15453394; KS-00000TON; EX-A783; MolPort-042-663-560; Avitinib(AC0010/AC0010MA); ZINC142081723; AKOS030632728; CS-W008904; N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide; DS-19269; AK543905; 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 72734520
  CAS Number: CAS 1557267-42-1
  TTD Drug ID: DMQRL2Y

Molecule-Related Drug Atlas

Drug(s) Targeting EGFR messenger RNA (EGFR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EGFR antisense DNA	DMF7EX8	Head and neck cancer	2D42	Phase 1/2	[3]
CK-101	DMMVWSY	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[2]
Pyrotinib	DMW7K39	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
EGFR messenger RNA (EGFR mRNA)	TTG96HZ	EGFR_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT03856697) Abivertinib Maleate Versus Geifitinib in Patients With Advanced Non-small Cell Lung Cancer With Sensitive EGFR Mutation. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Antitumor Effects of EGFR Antisense Guanidine-Based Peptide Nucleic Acids in Cancer Models. ACS Chem Biol. 2013 February 15; 8(2): 345-352.