Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQTAGO)

Drug Name

BMS-201038 Drug Info

Synonyms

AEGR 733; AEGR733; BMS 201038; BMS 201238; BMS201038; AEGR-733; BMS 201038-01

Indication

Disease Entry	ICD 11	Status	REF
Familial hypercholesterolemia	5C80.00	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Microsomal triglyceride transfer protein (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SLx-4090	DMM3AI8	Diabetic complication	5A2Y	Phase 2	[3]
Granotapide	DMMZQ7V	Hyperlipidaemia	5C80	Phase 2	[4]
Implitapide	DMTN16K	Hyperlipidaemia	5C80	Phase 2	[5]
JNJ-16269110	DMPFG7H	Type-2 diabetes	5A11	Phase 2	[6]
KD020	DMZ416B	Kidney disease	GC2Z	Phase 1/2	[7]
GR-328713	DMUANK9	Arteriosclerosis	BD40	Discontinued in Phase 1	[8]
DIRLOTAPIDE	DM2MV9O	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Microsomal triglyceride transfer protein (MTTP)	TTUS1RD	MTP_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7439).
2	Dyslipidemia and cardiovascular diseases. Curr Opin Lipidol. 2009 Apr;20(2):157-8.
3	A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.
4	JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6.
5	Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan;11(1):67-70.
6	ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health.
7	Clinical pipeline report, company report or official report of Kadmon Pharmaceuticals.
8	Patent CN101237870 B.
9	In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlota... Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9.