Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQVFWJ)

Drug Name
Para-Mercury-Benzenesulfonic Acid Drug Info
Synonyms
(4-sulfophenyl)mercury; 4-Mercuriphenylsulfonate; PARA-MERCURY-BENZENESULFONIC ACID; p-mercuribenzenesulfonic acid; 17014-79-8; PMBS; p-Mercuriphenylsulfonate; para-Mercuriphenylsulfonate; Mercury, bis(4-sulfophenyl)-; SCHEMBL3980997; AC1L22X1; CHEBI:49823; DTXSID30168809
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
65258
ChEBI ID
CHEBI:49823
CAS Number
CAS 17014-79-8
TTD Drug ID
DMQVFWJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [2]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [3]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [4]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [5]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [6]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [7]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [8]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [9]
Erteberel DMU1XZD Prostate hyperplasia GA90 Phase 2 [10]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Inhibitor [1]

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92.
5 Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15133-6.
6 MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause. 2009 May-Jun;16(3):458-65.
7 Company report (Axcentua)
8 S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.
9 Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031986)
11 Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536.