Details of the Drug-Related molecule(s) Interaction Atlas

BDBM50444062 Drug Info

CHEMBL3092765; SCHEMBL16438343; BDBM50444062

Cross-matching ID

PubChem CID

72792975

TTD Drug ID

DMR2UGC

General Information of Drug (ID: DMR2UGC)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting TYRO3 tyrosine kinase receptor (TYRO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RXDX-106	DM6NVTR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
BDBM50444058	DM9GLQB	N. A.	N. A.	Patented	[1]
KRDULPYOVRWKMA-UHFFFAOYSA-N	DMRY7KV	N. A.	N. A.	Patented	[3]
BDBM50444059	DMS0EMU	N. A.	N. A.	Patented	[1]
US10053465, 8	DM42XWO	N. A.	N. A.	Patented	[3]
US10053465, 12	DMPM8VB	N. A.	N. A.	Patented	[4]
US10053465, 5	DMV7BF2	N. A.	N. A.	Patented	[4]
LDC1267	DMH7R6L	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TYRO3 tyrosine kinase receptor (TYRO3)	TTIEMFN	TYRO3_HUMAN	Inhibitor	[1]

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References

1	Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309.
2	National Cancer Institute Drug Dictionary (drug name RXDX106).
3	Pyrrolopyrimidine derivatives as TAM inhibitors. US10053465.
4	Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors. US9708333.
5	The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12.