Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR35U4)

Drug Name

AMXT1501 Drug Info

Synonyms

(S)-N-(5-Amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide; 441022-64-6; CHEMBL474784; SCHEMBL10033849; N-(N6-Palmitoyl-L-lysyl)-4,9-diazadodecane-1,12-diamine

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

PubChem CID: 9916009
TTD Drug ID: DMR35U4

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polyamine transport (Poly trans)	TTJR4Z5	NOUNIPROTAC	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT03536728) Oral AMXT 1501 Dicaprate in Combination With DFMO. U.S. National Institutes of Health.
2	AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133(6):1323-33.