Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRDQPT)

Drug Name

2-D08 Drug Info

Synonyms

144707-18-6; 2',3',4'-trihydroxyflavone; 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one; SCHEMBL1772778; CHEMBL3115475; AOB4275; SYN5001; AMY31051; BCP18314; EX-A3562; MFCD27995567; s8696; ZINC97439024; CCG-267148; AC-31428; AK312791; AS-16368; HY-114166; 2D08;2 D08; CS-0077855; A16852; 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Preclinical	[1]

Cross-matching ID

PubChem CID: 22507438
TTD Drug ID: DMRDQPT

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Small ubiquitin-related modifier (SUMO)	TTW30FR	SUMO1_HUMAN; SUMO2_HUMAN; SUMO3_HUMAN; SUMO4_HUMAN; SUMO5_HUMAN	Inhibitor	[2]

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References

1	2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):1063-1069.
2	Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1. J Cell Sci. 2019 Oct 22;132(20):jcs234120.