Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMREF31)

• Drug Name: 2,6-diamino-5-nitropyrimidin-4(3H)-one Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135461662
  CAS Number: CAS 3346-23-4
  TTD Drug ID: DMREF31

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Dihydropteroate synthetase (Bact folP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[2]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[3]
Doripenem	DM9UCJK	Cholecystitis		Approved	[4]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[5]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[6]
Sulfisoxazole	DMXLT8C	Acute otitis media	AB00	Approved	[7]
Sulfapyridine	DMIUYFH	Dermatitis herpetiformis	EB44	Approved	[8]
Gramicidin D	DMPT74U	Bacterial infection	1A00-1C4Z	Approved	[9]
Oritavancin	DM28D05	Bacterial infection	1A00-1C4Z	Approved	[4]
Faropenem	DMX7A5V	Gram-positive bacterial infection	1B74-1G40	Approved	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydropteroate synthetase (Bact folP)	TT4ILYC	DHPS_ECOLI	Inhibitor	[1]

References

• [1] Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem. 2010 Jan 14;53(1):166-77.
• [2] In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
• [3] Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
• [4] Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
• [5] Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
• [6] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [7] Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
• [8] A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
• [9] Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.