Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRL6W5)

Drug Name
BAY2402234 Drug Info
Synonyms KNVJMHHAXCPZHF-JTQLQIEISA-N; BAY-2402234; SCHEMBL20108031; HY-112645; CS-0058850
Indication
Disease Entry ICD 11 Status REF
Myeloid leukaemia 2B33.1 Phase 1 [1]
Cross-matching ID
PubChem CID
134470179
CAS Number
CAS 2225819-06-5
TTD Drug ID
DMRL6W5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dihydroorotate dehydrogenase (DHODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [2]
Vidofludimus DM0POWG Inflammatory bowel disease DD72 Phase 2 [3]
BREQUINAR DMKGM42 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
LAS-186323 DMV80DP Multiple sclerosis 8A40 Phase 1 [5]
HR325 DM51GZS Rheumatoid arthritis FA20 Discontinued in Phase 2 [6]
FK778 DMH6QAI Kidney/heart transplant rejection NE84 Discontinued in Phase 2 [7]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dihydroorotate dehydrogenase (DHODH) TTLVP78 PYRD_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3 Company report (4SC)
4 DOI: 10.1203/00006450-198807000-00137
5 Clinical pipeline report, company report or official report of Aslanpharma.
6 In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.
7 Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.