Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRNGD2)

Drug Name

Daprodustat Drug Info

Synonyms

GSK1278863; Daprodustat; 960539-70-2; GSK1278863; UNII-JVR38ZM64B; GSK-1278863; JVR38ZM64B; N-((1,3-Dicyclohexylhexahydro-2,4,6-trioxopyrimidin-5-yl)carbonyl)glycine; Daprodustat [USAN:INN]; GSK 1278863; Daprodustat(GSK1278863); Daprodustat; GSK1278863; Daprodustat (JAN/USAN/INN); GTPL8455; Daprodustat (GSK1278863); CHEMBL3544988; KS-00000M8Z; EX-A1121; BCP16766; s8171; AKOS027439964; Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-; ZINC231226004; CS-5453; SB19761; DB11682; HY-17608; J3.560.573H; D10874

Indication

Disease Entry	ICD 11	Status	REF
Anaemia	3A90	Approved	[1]
Autism spectrum disorder	6A02	Phase 2	[2]
Diabetic foot ulcer	BD54	Phase 1	[3]

Cross-matching ID

PubChem CID: 91617630
CAS Number: CAS 960539-70-2
TTD Drug ID: DMRNGD2
INTEDE Drug ID: DR1824

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting HIF-prolyl hydroxylase 1 (HPH-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FG-4592	DM4XSQ2	Anaemia	3A90	Phase 3	[6]
BAY-85-3934	DM7NHLC	Anemia	3A00-3A9Z	Phase 2	[7]
Pyridine-2,4-dicarboxylic acid	DM4G8WX	Discovery agent	N.A.	Investigative	[8]
2-(carboxymethylamino)-2-oxoacetic acid	DMQ2SNL	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[12]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[13]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[14]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[10]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[15]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 1 (HPH-1)	TTMHFRY	EGLN2_HUMAN	Inhibitor	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C8 (CYP2C8)^{Main DME}	DES5XRU	CP2C8_HUMAN	Substrate	[5]

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References

1	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 216951.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8455).
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
5	Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8.
6	The latest advances in kidney diseases and related disorders. Drug News Perspect. 2007 Dec;20(10):647-54.
7	Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One. 2014 Nov 13;9(11):e111838.
8	Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone de... J Med Chem. 2010 Aug 12;53(15):5629-38.
9	Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
10	Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
11	Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
12	Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75.
13	Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
14	Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8.
15	PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
16	Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.