Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMROZUA)

Drug Name
Pyroglutamic Acid Drug Info
Synonyms
DL-Pyroglutamic acid; 149-87-1; 5-Oxopyrrolidine-2-carboxylic acid; 2-Pyrrolidone-5-carboxylic acid; DL-Proline, 5-oxo-; 5-OXOPROLINE; 5-Oxo-DL-proline; Pyroglutamate; D-(+)-Pyroglutamic Acid; DL-Glutamic Acid Lactam; Pyrrolidonecarboxylic acid; CHEBI:16010; ODHCTXKNWHHXJC-UHFFFAOYSA-N; MFCD00064322; 5-oxoprolinate; DL-Pidolic acid; (+)-Pyroglutamic acid; 5-OXO-2-PYRROLIDINECARBOXYLIC ACID; D-Pyroglutamate; (+)-2-Pyrrolidone-5-carboxylic acid; DL-5-Oxoproline; (D-5-Oxo-2-pyrrolidinecarboxylic acid); Proline,5-oxo-; 5-Oxoproline #
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7405
ChEBI ID
CHEBI:18183
CAS Number
CAS 98-79-3
TTD Drug ID
DMROZUA
VARIDT Drug ID
DR00293

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
Drug Status:
Investigative Drug(s)
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Angiogenin (ANG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrophosphate 2- DMZQ75M Discovery agent N.A. Investigative [4]
Drug(s) Targeting Pancreatic alpha-amylase (AMY2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pancrecarb DMOML9Q Pancreatic malfunction DC30-DC3Z NDA filed [5]
Liprotamase DMNF4UH Cystic fibrosis CA25 Phase 3 [6]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [2]
Acanthus ilicifolius Linn DMZDFRI Discovery agent N.A. Investigative [7]
6-Deoxy-Alpha-D-Glucose DM9HBY5 Discovery agent N.A. Investigative [2]
Acarbose Derived Hexasaccharide DMS9COH Discovery agent N.A. Investigative [2]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam DMMY542 Discovery agent N.A. Investigative [8]
Hydroxycitric acid DMY0A9E Discovery agent N.A. Investigative [9]
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen DM4IXUQ Discovery agent N.A. Investigative [10]
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen DMHV14R Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Monocarboxylate transporter 1 (SLC16A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [12]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [12]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [13]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [14]
Gabapentin enacarbil DMJY2TM Postherpetic neuralgia 1E91.5 Phase 2 [15]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [15]
Hydroxyacetic Acid DMQFBH6 Discovery agent N.A. Investigative [16]
biotin DMKMCE1 Discovery agent N.A. Investigative [17]
Milchsaure DM462BT Pruritus EC90 Investigative [18]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiogenin (ANG) TTURHFP ANGI_HUMAN Inhibitor [2]
Orexin (HCRT) TTU5HJP OREX_HUMAN Inhibitor [2]
Pancreatic alpha-amylase (AMY2A) TTCGSZ4 AMYP_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Monocarboxylate transporter 1 (SLC16A1) DT342ZG MOT1_HUMAN Substrate [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4703).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Interaction of atorvastatin with the human glial transporter SLC16A1. Eur J Pharmacol. 2016 Oct 5;788:248-254.
4 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5 Clinical pipeline report, company report or official report of Digestive Care.
6 Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
7 Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92.
8 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
9 Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82.
10 Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30.
11 Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):904-17.
12 H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19.
13 Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos. 2007 Feb;35(2):201-8.
14 AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30.
15 Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21.
16 Cidofovir peptide conjugates as prodrugs. Journal of Organometallic Chemistry, 2005, 690(10):2673-2678.
17 Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46.
18 Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9.