Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRVHWZ)

Drug Name
PIPERROLEIN B Drug Info
Synonyms
Piperolein B; PIPERROLEIN B; Piperoleine B; 30505-89-6; CHEMBL256214; MEGxp0_000205; SCHEMBL15471329; ACon1_000259; FAXXHNWVMKTOFF-UXBLZVDNSA-N; MCULE-4025815326; NCGC00180733-01; BRD-K04771916-001-01-8; Piperidine, 1-[(8E)-9-(1,3-benzodioxol-5-yl)-1-oxo-8-nonenyl]-; (8E)-9-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)non-8-en-1-one; Piperidine, 1-[9-[3,4-(methylenedioxy)phenyl]-8-nonenoyl]-, (E)-; (E)-9-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)non-8-en-1-one; Piperidine, 1-[9-(1,3-benzodioxol-5-yl)-1-oxo-8-nonenyl]-, (
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
21580213
CAS Number
CAS 30505-89-6
TTD Drug ID
DMRVHWZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
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Drug(s) Targeting ICAM1 messenger RNA (ICAM1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 1570 DMJ9G23 Lleum inflammation 1A40.0 Approved [2]
Alicaforsen DMQ509J Lleum inflammation 1A40.0 Phase 3 [3]
INXC-ICAM1 DMODQW0 Transplant rejection NE84 Terminated [4]
A-286982 DM98VFW Discovery agent N.A. Investigative [5]
ISIS 11159 DM9V6FW Discovery agent N.A. Investigative [6]
ISIS 3224 DMAFEYG Discovery agent N.A. Investigative [6]
ISIS 1931 DMBMQNI Discovery agent N.A. Investigative [2]
ISIS 2974 DM7K19L Discovery agent N.A. Investigative [2]
Dehydropipernonaline DMIOA9M Discovery agent N.A. Investigative [1]
ISIS 3067 DMC9OL7 Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ICAM1 messenger RNA (ICAM1 mRNA) TTA1L39 ICAM1_HUMAN Inhibitor [1]

References

1 Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6.
2 US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
3 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
4 ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6.
5 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
6 US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.