Details of the Drug-Related molecule(s) Interaction Atlas

KRDULPYOVRWKMA-UHFFFAOYSA-N Drug Info

CHEMBL2216867; SCHEMBL2014247; KRDULPYOVRWKMA-UHFFFAOYSA-N; BDBM50004539; N-{1-[5-Chloro-8-(3-fluorophenyl)cinnolin-7-yl]ethyl}-9H-purin-6-amine

Cross-matching ID

PubChem CID

53235521

TTD Drug ID

DMRY7KV

General Information of Drug (ID: DMRY7KV)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting TYRO3 tyrosine kinase receptor (TYRO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RXDX-106	DM6NVTR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
BDBM50444058	DM9GLQB	N. A.	N. A.	Patented	[3]
BDBM50444062	DMR2UGC	N. A.	N. A.	Patented	[3]
BDBM50444059	DMS0EMU	N. A.	N. A.	Patented	[3]
US10053465, 8	DM42XWO	N. A.	N. A.	Patented	[1]
US10053465, 12	DMPM8VB	N. A.	N. A.	Patented	[4]
US10053465, 5	DMV7BF2	N. A.	N. A.	Patented	[4]
LDC1267	DMH7R6L	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TYRO3 tyrosine kinase receptor (TYRO3)	TTIEMFN	TYRO3_HUMAN	Inhibitor	[1]

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References

1	Pyrrolopyrimidine derivatives as TAM inhibitors. US10053465.
2	National Cancer Institute Drug Dictionary (drug name RXDX106).
3	Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309.
4	Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors. US9708333.
5	The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12.