Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS0LCZ)

Drug Name

ARX-201 Drug Info

Synonyms

PEG-ahGH; PEG-hGH variants (growth disorders), Ambrx; PEG-human growth hormone variants (ReCODE, growth disorders), Ambrx; 30KPEG-N1-pAFhGH; 30PEG-N4-pAFhGH

Indication

Disease Entry	ICD 11	Status	REF
Growth failure	LD2F.1Y	Discontinued in Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMS0LCZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lonapegsomatropin	DMPR8E9	Growth failure	LD2F.1Y	Approved	[3]
HGH-CTP	DMXAZ47	Growth hormone deficiency	5A61.3	Phase 3	[4]
Albutropin	DMWAL73	Growth failure	LD2F.1Y	Phase 3	[5]
VRS-317	DMWMT5N	Growth hormone deficiency	5A61.3	Phase 3	[6]
Somatropin intranasal rhGH	DMK3RL8	Growth hormone deficiency	5A61.3	Phase 2	[7]
YPEG-Somatropin	DMCM0K6	Growth hormone deficiency	5A61.3	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatotropin (GH1)	TTT3YKH	SOMA_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022324)
2	Company report (Avarx)
3	ClinicalTrials.gov (NCT01947907) Safety, PK/PD and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD). U.S. National Institutes of Health.
4	Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int J Nanomedicine. 2014; 9: 3527-3538.
5	Albutropin: a growth hormone-albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys. Eur J Pharmacol. 2002 Dec 5;456(1-3):149-58.
6	Company report (Versartis)
7	Long-term efficacy and safety of somatropin for adult growth hormone deficiency.Treat Endocrinol.2003;2(2):109-20.
8	Somatropin therapy in adults with Prader-Willi syndrome. Treat Endocrinol. 2004;3(3):153-60.