Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS9I6A)

Drug Name

AZD7687 Drug Info

Synonyms

AZD7687; 1166827-44-6; CHEMBL2178944; CHEMBL2178953; AZD-7687; AZD 7687; UNII-6QTJ9P2NYT; 6QTJ9P2NYT; SCHEMBL2252415; SCHEMBL5532381; SCHEMBL2252417; GTPL7827; SCHEMBL2255196; DTXSID60655297; YXFNPRHZMOGREC-SHTZXODSSA-N; 3466AH; ZINC43206395; BDBM50399684; BDBM50399710; AZD 7687;AZD-7687; ZINC101581684; AKOS030526281; CS-1026; NCGC00378858-01; HY-15497; KB-144428; W-5990; {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid; {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 1	[1]
Obesity	5B81	Phase 1	[1]

Cross-matching ID

PubChem CID: 42636350
CAS Number: CAS 1166827-44-6
TTD Drug ID: DMS9I6A

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Diacylglycerol acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[3]
LCQ908	DMFLJHQ	Familial chylomicronemia syndrome	5C80	Phase 3	[4]
P-7435	DMNZQU5	Diabetic complication	5A2Y	Phase 1	[5]
PMID25470667-Compound-Figure4-1A	DMMVQW8	N. A.	N. A.	Patented	[6]
Azole derivative 7	DMVUJGI	N. A.	N. A.	Patented	[6]
Carbamide derivative 3	DM4ISCQ	N. A.	N. A.	Patented	[6]
T863	DMX41ZF	Discovery agent	N.A.	Patented	[6]
Benzamide derivative 19	DM5YNTM	N. A.	N. A.	Patented	[6]
Lactam derivative 5	DMX5FYZ	N. A.	N. A.	Patented	[6]
Pyridine-carboximide derivative 2	DMHXWZB	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol acyltransferase 1 (DGAT1)	TTF8P9I	DGAT1_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7827).
2	Clinical pipeline report, company report or official report of AstraZeneca (2011).
3	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
4	DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)
6	Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.