Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS9I6A)

Drug Name
AZD7687 Drug Info
Synonyms
AZD7687; 1166827-44-6; CHEMBL2178944; CHEMBL2178953; AZD-7687; AZD 7687; UNII-6QTJ9P2NYT; 6QTJ9P2NYT; SCHEMBL2252415; SCHEMBL5532381; SCHEMBL2252417; GTPL7827; SCHEMBL2255196; DTXSID60655297; YXFNPRHZMOGREC-SHTZXODSSA-N; 3466AH; ZINC43206395; BDBM50399684; BDBM50399710; AZD 7687;AZD-7687; ZINC101581684; AKOS030526281; CS-1026; NCGC00378858-01; HY-15497; KB-144428; W-5990; {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid; {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Phase 1 [1]
Obesity 5B81 Phase 1 [1]
Cross-matching ID
PubChem CID
42636350
CAS Number
CAS 1166827-44-6
TTD Drug ID
DMS9I6A

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Diacylglycerol acyltransferase 1 (DGAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [3]
LCQ908 DMFLJHQ Familial chylomicronemia syndrome 5C80 Phase 3 [4]
P-7435 DMNZQU5 Diabetic complication 5A2Y Phase 1 [5]
PMID25470667-Compound-Figure4-1A DMMVQW8 N. A. N. A. Patented [6]
Azole derivative 7 DMVUJGI N. A. N. A. Patented [6]
Carbamide derivative 3 DM4ISCQ N. A. N. A. Patented [6]
T863 DMX41ZF Discovery agent N.A. Patented [6]
Benzamide derivative 19 DM5YNTM N. A. N. A. Patented [6]
Lactam derivative 5 DMX5FYZ N. A. N. A. Patented [6]
Pyridine-carboximide derivative 2 DMHXWZB N. A. N. A. Patented [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Diacylglycerol acyltransferase 1 (DGAT1) TTF8P9I DGAT1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7827).
2 Clinical pipeline report, company report or official report of AstraZeneca (2011).
3 In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
4 DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)
6 Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.