Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSH107)

Drug Name

6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione Drug Info

Synonyms

CHEMBL54950; 64054-69-9; 6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione; 6-[(5-Indanyl)amino]uracil; SCHEMBL3971654; CTK2A7431; DTXSID80591769; BDBM50022163; ZINC13798089; 6-[(3,4-trimethylene)anilino]uracil; 2,4(1H,3H)-Pyrimidinedione, 6-[(2,3-dihydro-1H-inden-5-yl)amino]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 17960612
CAS Number: CAS 64054-69-9
TTD Drug ID: DMSH107

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting DNA topoisomerase (TOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[2]
Icofungipen	DMTXNZK	Fungal infection	1F29-1F2F	Phase 2	[3]
TOPOSTATIN	DMNZQO9	Discovery agent	N.A.	Investigative	[4]
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione	DMKUHN9	Discovery agent	N.A.	Investigative	[1]
N4-Benzyl-6-chloro-pyrimidine-2,4-diamine	DMNGSQK	Discovery agent	N.A.	Investigative	[5]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione	DMTPRIW	Discovery agent	N.A.	Investigative	[5]
6-Benzylamino-1H-pyrimidine-2,4-dione	DM8FUZL	Discovery agent	N.A.	Investigative	[5]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione	DMMFWYX	Discovery agent	N.A.	Investigative	[1]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione	DMGJYWF	Discovery agent	N.A.	Investigative	[5]
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one	DMECHD0	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase (TOP)	TT2GPK3	NOUNIPROTAC	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
4	Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.
5	Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.