Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSMQGL)

Drug Name

GSK3494245 Drug Info

Synonyms

GSK3494245; DDD01305143; GSK-3494245; DDD-01305143; T7XAE9Y6B9; 2080410-41-7; N-(4-Fluoro-3-(3-morpholinoimidazo(1,2-a)pyrimidin-7-yl)phenyl)pyrrolidine-1-carboxamide; N-(4-fluoro-3-(3-morpholinoimidazo[1,2-a]pyrimidin-7-yl)phenyl)pyrrolidine-1-carboxamide; 1-Pyrrolidinecarboxamide, N-(4-fluoro-3-(3-(4-morpholinyl)imidazo(1,2-a)pyrimidin-7-yl)phenyl)-; N-(4-Fluoro-3-(3-(4-morpholinyl)imidazo(1,2-a)pyrimidin-7-yl)phenyl)-1-pyrrolidinecarboxamide; UNII-T7XAE9Y6B9; CHEMBL5095239; SCHEMBL18495650; BDBM50601512; MS-27077; HY-127102; CS-0093101; GSK3494245/DDD01305143

Indication

Disease Entry	ICD 11	Status	REF
Visceral leishmaniasis	1F54.0	Phase 1	[1]

Cross-matching ID

PubChem CID: 126571915
TTD Drug ID: DMSMQGL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Proteasome (PS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bortezomib	DMNO38U	Leukemia		Approved	[3]
MLN9708	DMCMETN	Amyloidosis	5D00	Approved	[4]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[5]
Marizomib	DME9QGW	Glioblastoma of brain	2A00.00	Phase 3	[6]
Oprozomib	DM16RIC	Hodgkin lymphoma	2B30	Phase 2	[7]
Delanzomib	DMX4DQH	Multiple myeloma	2A83	Phase 2	[8]
PS-519	DMI0WHC	Ischemia-reperfusion injury	DB98.B	Terminated	[9]
MG-101	DM3RUT8	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04504435) A Randomized, Double-blind, Placebo-controlled, First Time in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single (in Both Fed and Fasted States) Doses of GSK3494245 in Healthy Participants. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.
5	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
6	Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar;11(3):254-84.
7	A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood. 2010 Dec 2;116(23):4906-15.
8	Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE. Int Immunopharmacol. 2012 Jan;12(1):257-70.
9	Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in... Neurotox Res. 2003;5(7):505-14.
10	Covalent complexes of proteasome model with peptide aldehyde inhibitors MG132 and MG101: docking and molecular dynamics study.J Mol Model.2009 Dec;15(12):1481-90.