Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSUPCD)

• Drug Name: 1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol Drug Info
• Synonyms: CHEMBL37989

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 13626879
  TTD Drug ID: DMSUPCD

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[2]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[3]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[4]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[5]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[5]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[5]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[6]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[7]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[8]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[9]

Drug(s) Targeting Adrenergic receptor beta-3 (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mirabegron	DMS1GYT	Overactive bladder	GC50.0	Approved	[10]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[11]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[12]
Bopindolol	DMIFYLX	Hypertension	BA00-BA04	Approved	[13]
Mepindolol	DMUDWP9	Angina pectoris	BA40	Approved	[14]
Rimiterol	DMA47C6	Asthma	CA23	Approved	[15]
Bitolterol	DMK6XAV	Chronic obstructive pulmonary disease	CA22	Approved	[16]
Nipradilol	DMA65ER	Angina pectoris	BA40	Approved	[17]
Vibegron	DMFR201	Overactive bladder	GC50.0	Approved	[18]
ONO-2506	DMCA2PJ	Stroke	8B20	Phase 2/3	[19]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Inhibitor	[1]

References

• [1] Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols. J Med Chem. 1986 Aug;29(8):1524-7.
• [2] Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
• [3] Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77.
• [4] Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31.
• [5] Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6.
• [6] Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95.
• [7] Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
• [8] beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):519-29.
• [9] beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.
• [10] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [11] Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
• [12] Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Mar;82(3):291-5.
• [13] Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S70-3.
• [14] Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol. Arzneimittelforschung. 1986 May;36(5):811-3.
• [15] Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8.
• [16] Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37.
• [17] Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
• [18] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [19] FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.