Details of the Drug-Related molecule(s) Interaction Atlas

US8754233, (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine Drug Info

SCHEMBL686607; CHEMBL3680986; BDBM123923; US8754233, (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine

Cross-matching ID

PubChem CID

66768033

TTD Drug ID

DMSYD3X

General Information of Drug (ID: DMSYD3X)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Integrin-linked protein kinase 1 (ILK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-fluoro-phenyl)-2H-pyrazol-3-ylamine	DMJY0CD	N. A.	N. A.	Patented	[1]
US8754233, 2-(3-Amino-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide	DMJPQNH	N. A.	N. A.	Patented	[1]
PMID21823616C22	DMXF32O	Discovery agent	N.A.	Investigative	[2]
MST-400	DMUKWJ2	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Integrin-linked protein kinase 1 (ILK)	TT7ALZG	ILK_HUMAN	Inhibitor	[1]

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References

1	Pyrazolylbenzothiazole derivatives and their use as therapeutic agents. US8754233.
2	Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2041).