General Information of Drug (ID: DMT0K4F)

Drug Name
MTR105 Drug Info
Synonyms
UNII-CTD25O6OBI; CTD25O6OBI; MTR 105; S-Ethylisothiuronium diethyl phosphate; 21704-46-1; Carbamimidothioic acid, ethyl ester, mono(diethyl phospate); Phosphoric acid, diethyl ester, compd. with 2-ethyl-2-thiopseudourea (1:1); Difetur; AC1Q6SNE; AC1L4PKY; CTK4E7529; nitric oxide synthase inhibi-tors; ethyl carbamimidothioate- diethyl hydrogen phosphate(1:1); MTR-105; DTXSID60176093; AKOS030611139; LS-107705; diethyl hydrogen phosphate; Carbamimidothioic acid, ethyl ester, diethyl phosphate (1
Indication
Disease Entry ICD 11 Status REF
Hypotension BA20-BA21 Phase 2 [1]
Cross-matching ID
PubChem CID
210823
CAS Number
CAS 21704-46-1
TTD Drug ID
DMT0K4F

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tilarginine acetate DMZBGI8 Myocardial infarction BA41-BA43 Phase 3 [3]
L-NAME DM01SR6 Hypertension BA00-BA04 Phase 2 [4]
ACCLAIM DM0FGDO Angina pectoris BA40 Phase 2 [5]
VAS-203 DMKU93J Brain injury NA07.Z Phase 2 [6]
Autologous cell based gene therapy DMQA1VT Pulmonary hypertension BB01 Phase 1 [7]
L-NIL DM6Y49D N. A. N. A. Terminated [8]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [9]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [9]
Heme DMGC287 Discovery agent N.A. Investigative [10]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00482287) Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients. U.S. National Institutes of Health.
2 Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. Cardiology. 2008;111(3):181-7.
3 Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA. 2007 Apr 18;297(15):1657-66.
4 Counter-regulation by atorvastatin of gene modulations induced by L-NAME hypertension is associated with vascular protection. Vascul Pharmacol. 2009 Oct;51(4):253-61.
5 CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
6 Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA). J Neurotrauma. 2014 Oct 1;31(19):1599-606.
7 Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Mol Ther. 2002 Sep;6(3):422-8.
8 Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.