Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT2EPG)

• Drug Name: 17alpha-hydroxypregnenolone Drug Info
• Synonyms: 17alpha hydroxypregnenolone; 17-OH-pregnenolone; 17-hydroxypregnenolone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 91451
  ChEBI ID: CHEBI:28750
  CAS Number: CAS 387-79-1
  TTD Drug ID: DMT2EPG
  INTEDE Drug ID: DR2031

Molecule-Related Drug Atlas

Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[4]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[5]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[2]
HE2100	DMCP2KH	Thrombocytopenia	3B64	Discontinued in Phase 1	[6]

Drug(s) Metabolized By Beta-HSD adrenal and gonadal type (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[4]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[5]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[7]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[2]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[8]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[12]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[13]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[14]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[14]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[15]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-HSD adrenal and gonadal type (HSD3B2)	DEN0GVQ	3BHS2_HUMAN	Substrate	[2]
Dihydrotestosterone oxidoreductase (HSD3B1)	DERDQWN	3BHS1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Biotransformations	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5103).
• [2] Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
• [3] Functional characterization of mutant CYP17 genes isolated from a 17 alpha-hydroxylase/17,20-lyase-deficient patient. Metabolism. 2004 Dec;53(12):1527-31. doi: 10.1016/j.metabol.2004.05.018.
• [4] Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65.
• [5] Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81.
• [6] Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
• [7] Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
• [8] Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Aug;90(8):4858-65. doi: 10.1210/jc.2005-0330. Epub 2005 May 24.
• [9] Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
• [10] Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
• [11] Use of organ culture to study the human fetal testis development: effect of retinoic acid. J Clin Endocrinol Metab. 2006 Jul;91(7):2696-703.
• [12] Inhibition of CYP17 expression by adrenal androgens and transforming growth factor beta in adrenocortical cells. Acta Biochim Pol. 2004;51(4):907-17.
• [13] Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem. 2008 Mar 14;283(11):6925-34. doi: 10.1074/jbc.M708432200. Epub 2008 Jan 9.
• [14] Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
• [15] A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21. J Enzyme Inhib Med Chem. 2006 Oct;21(5):547-56.