Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT2EPG)

Drug Name

17alpha-hydroxypregnenolone Drug Info

Synonyms

17alpha hydroxypregnenolone; 17-OH-pregnenolone; 17-hydroxypregnenolone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[3]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[4]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[2]
HE2100	DMCP2KH	Thrombocytopenia	3B64	Discontinued in Phase 1	[5]
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Drug(s) Metabolized By Beta-HSD adrenal and gonadal type (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[3]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[4]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[6]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-HSD adrenal and gonadal type (HSD3B2)	DEN0GVQ	3BHS2_HUMAN	Substrate	[2]
Dihydrotestosterone oxidoreductase (HSD3B1)	DERDQWN	3BHS1_HUMAN	Substrate	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5103).
2	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801.
3	Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65.
4	Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81.
5	Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
6	Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.