Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT73J8)

Drug Name

Luliconazole Drug Info

Synonyms

Lulicon; Lulifin; JA-004; JA-005; NND-502; PR-2699

Indication

Disease Entry	ICD 11	Status	REF
Tinea corporis	1F28.Y	Approved	[1]
Tinea cruris	1F28.3	Approved	[1]
Tinea pedis	1F28.2	Approved	[2]
Dry eye disease	9E1Z	Phase 2/3	[3]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Candida Cytochrome P450 51 (Candi ERG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[5]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[5]
Posaconazole	DMUL5EW	Aspergillosis	1F20	Approved	[6]
Ketoconazole	DMPZI3Q	Blastomycosis	1F22	Approved	[7]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[5]
Oxiconazole	DME7KRM	Tinea corporis	1F28.Y	Approved	[8]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[5]
Terconazole	DMJ13KI	Candidiasis	1F23	Approved	[9]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[10]
Tioconazole	DMNYPGS	Onychomycosis	EE12.1	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Cytochrome P450 51 (Candi ERG11)	TTTSOUD	CP51_CANAL	Inhibitor	[4]

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References

1	Luliconazole FDA Label
2	Clinical pipeline report, company report or official report of Valeant pharmaceuticals.
3	Clinical pipeline report, company report or official report of Topica Pharmaceuticals.
4	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6.
7	Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
8	Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9.
9	Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.
10	Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7.
11	Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6.