Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT80IF)

Drug Name

3570-0208 Drug Info

Synonyms

[6-ethyl-2-methyl-3-(1-methylbenzimidazol-2-yl)-4-oxochromen-7-yl] acetate; UNM000003536701; AC1MJIQD; BAS 00135206; Oprea1_681432; Oprea1_151337; MLS001242385; GTPL5828; CHEMBL1329101; cid_3092570; CHEBI:92290; BDBM40404; ML048; HMS2231A24; HMS3372G14; ZINC4247033; STK922580; AKOS000525202; MCULE-3542011334; SMR000686159; ST50330694; EU-0040874; SR-01000456743; SR-01000456743-1; 3570-0208 [PMID:19807662]; 2-methyl-3-(1-methyl-2-benzimidazolyl)-6-ethyl-7-acetoxychromone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3092570
ChEBI ID: CHEBI:92290
TTD Drug ID: DMT80IF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting N-formyl peptide receptor (FPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rebamipide	DM2GHCR	Peptic ulcer	DA61	Phase 3	[2]
PMID22607879CR-(-)-5f	DM7OJ5Q	Discovery agent	N.A.	Investigative	[3]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[4]
pyrazolone, 1	DMLFQKU	Discovery agent	N.A.	Investigative	[5]
group E 1682-2106	DMO6IM1	Discovery agent	N.A.	Investigative	[6]
BVT173187	DMULZOP	Discovery agent	N.A.	Investigative	[7]
CGEN-855	DM4FMPJ	Inflammation	1A00-CA43.1	Investigative	[8]
AG-11/03	DMZINUY	Discovery agent	N.A.	Investigative	[9]
methionine benzimidazole 6	DMEIP6H	Discovery agent	N.A.	Investigative	[10]
AG-09/1	DMW7H28	Discovery agent	N.A.	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-formyl peptide receptor (FPR1)	TT5Y4EM	FPR1_HUMAN	Antagonist	[1]

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References

1	Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Curr Top Med Chem. 2009;9(13):1227-36.
2	Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. J Pharmacol Exp Ther. 2001 Apr;297(1):388-94.
3	Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92.
4	Further studies on the structural requirements for synthetic peptide chemoattractants. Biochemistry. 1980 May 27;19(11):2404-10.
5	Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol. 2013 Feb;83(2):389-98.
6	Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol. 2005 Nov;68(5):1301-10.
7	A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1. Biochem Pharmacol. 2012 Jun 15;83(12):1655-62.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 222).
9	Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1. J Mol Model. 2012 Jun;18(6):2831-43.
10	Discovery of small molecule human FPR1 receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7.
11	Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol Pharmacol. 2010 Feb;77(2):159-70.