Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTBAXD)

Drug Name

[3H]A317491 Drug Info

Synonyms

A-317491; 475205-49-3; UNII-H327N08IPV; H327N08IPV; A 317491; 5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid; A317491; VQGBOYBIENNKMI-LJAQVGFWSA-N; antagonist A-317491; [3H]A-317491; [3H]A 317491; SCHEMBL1160095; GTPL5407; GTPL4115; CHEMBL596234; CTK4J0070; BDBM86478; DTXSID40197185; MolPort-028-749-920; ZINC3990058; s8519; 475205-49-3 (free acid); AKOS030526820; CS-1250; NCGC00165956-01; 1,2,4-Benzenetricarboxylic acid,; [3H]A-317491

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9829395
CAS Number: CAS 475205-49-3
TTD Drug ID: DMTBAXD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting P2X purinoceptor 3 (P2RX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefapixant	DM4GWL7	Cough	MD12	Phase 3	[3]
BAY-1902607	DMYSQMW	Cough	MD12	Phase 2	[3]
BAY 1902607	DMFA4CK	Cough	MD12	Phase 1/2	[3]
AF-130	DM8LG2I	Hypertension	BA00-BA04	Phase 1	[4]
BAY-1817080	DMNL5G7	Endometriosis	GA10	Phase 1	[3]
BAY 1817080	DMF9ALP	Cough	MD12	Phase 1	[5]
BzATP	DM37GYA	Discovery agent	N.A.	Investigative	[6]
TNP-ATP	DMVZY0X	Discovery agent	N.A.	Investigative	[7]
ISOPPADS	DMWI0M8	Discovery agent	N.A.	Investigative	[8]
LVAYPWT	DMIO405	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2X purinoceptor 3 (P2RX3)	TT2THBD	P2RX3_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5407).
2	Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol. 2003 Dec 15;553(Pt 3):683-94.
3	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 480).
7	Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73.
8	Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem. 2001 Feb 1;44(3):340-9.
9	Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7.